Product introduction：
CAS: 936563-96-1
MF: C25H24N6O2
Loss on drying: ≤1.0%
Purity: ≥99.0%
Description: Purity 99% Ibrutinib powder cas 936563-96-1 is an inhibitor of Bruton tyrosine kinase (BTK) for the treatment of chronic lymphoblastic leukemia (CLL) and sleeve cell lymphoma (MCL).
Application:
1. Purity 99% Ibrutinib powder cas 936563-96-1 is used for Chronic graft-versus-host (cGVHD) disease after failure of one or more prior lines of systemic therapy.
2. Chronic lymphocytic leukemia (CLL) who have received at least one prior therapy.
3. Mantle cell lymphoma (MCL) who have received at least one prior therapy.
4. Marginal zone lymphoma (MZL) who require systemic therapy and have received at least one prior anti-CD20-based therapy.
5. Waldenstrom's macroglobulinemia.
Certificate of analysis
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Items
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Standard
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Results
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Description
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White To off-white powder
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White powder
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Solubility
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Soluble in tetrahydrofuran, slightly soluble in methanol,
dichloromethane or acetonitrile, slightly soluble in toluene,
practically insoluble in water
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Conforms
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Identification
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Should be accaordence with reference
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Conforms
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Water
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≤1.5%
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0.05%
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Solvent
residue
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THF≤720ppm
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400ppm
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Methylbenzene≤890ppm
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not detected
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Methanol≤3000ppm
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30ppm
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Dichloromethane≤600ppm
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250ppm
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Ethyl acetate≤5000ppm
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not detected
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Residue on ignition
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≤0.2%
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0.07%
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Heavy metals
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≤20ppm
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Conforms
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Related substances
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Single impurity
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≤0.2%
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0.04%
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Total impurity
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≤2.0%
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0.27%
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Assay
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97.0%—103.0%
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100.4%
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