Product introduction
Product name: 5-aMino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile
Cas: 330792-70-6
MF: C16H12N4O
Appearance: Light yellow to off-white powder
Assay: ¡Ý98.5%
Maxium single impurity: ¡Ü1.0%
Total impurity: ¡Ü0.2%
Loss on drying: ¡Ü1.0£¥
Residue on ignition: ¡Ü0.2%
Heavy metals: ¡Ü20ppm
Molecular Weight: 276.29
Application: 3-Amino-5-(4-phenoxyphenyl)-4-cyano-1H-pyrazole is an intermediate used in the synthesis of ibrutinib, which is a Bruton's tyrosine kinase (BTK) inhibitor for the treatment of chronic lymphocytic leukemia (CChemicalbookLL) and mantle cell lymphoma (MCL). Ibrutinib can target BTK necessary for the formation, differentiation, information transmission and survival of B lymphocytes, irreversibly inhibit the activity of BTK, and effectively inhibit the proliferation and survival of tumor cells.
Specification
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TESTS
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SPECIFICATIONS
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RESULTS
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Appearance
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Light yellow to off-white powder
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Off-white poeder
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Related substance
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Maxium single impurity
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¡Ü1.0%
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0.33%
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Total impurity
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¡Ü2.0%
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0.65%
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Loss on drying
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¡Ü1.0%
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0.49%
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Residue on ignition
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¡Ü0.2%
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Conforms
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Heavy metal
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¡Ü20ppm
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Conforms
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Assay
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¡Ý98.5%
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99.35%
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